[Proceedings of The National Academy of Sciences of The United States of America] Scientists identified DDX54 as a master regulator in immune-desert lung cancer with a high mutational burden, whose knockdown reduced resistance to immune checkpoint inhibitors.

[American Journal of Respiratory Cell and Molecular Biology] To investigate the role of tartrate-resistant acid phosphatase 5 (TRAP5) during asthma, scientists used a murine model of ovalbumin induced allergic airway inflammation as well as IL-33 induced airway inflammation including Trap5-/- and wild-type mice.

[Nature Communications] This single-arm, Phase II trial assessed the feasibility of neoadjuvant Aumolertinib for unresectable stage III EGFR-mutant NSCLC.

[Journal of Experimental & Clinical Cancer Research] circRNA differential expression profiles in lung cancer were revealed via RNA high-throughput sequencing, and circKIAA1797 expression in lung cancer cell lines and tissues was detected using qPCR.

[Respiratory Research] Bronchoalveolar lavage cells from two populations of healthy and asthmatic horses were evaluated for cytology and Myristoylated Alanine Rich C Kinase Substrate (MARCKS) protein analysis.

[npj Vaccines] Researchers evaluated the effects of subcutaneous and sublingual allergen-specific immunotherapy with purified recombinant Art v 1 (rArt v 1) in a murine model of mugwort pollen of asthma.

[Therapeutic Advances in Respiratory Disease] The authors provide a comprehensive summary of the impact of elexacaftor, tezacaftor, and ivacaftor on clinical outcomes and the need for further research on long-term efficacy, side effects, pregnancy, possible drug–drug interactions, and extra-pulmonary manifestations.

[Regeneron Pharmaceuticals, Inc. ] Regeneron Pharmaceuticals, Inc. and Sanofi announced that the Ministry of Health, Labour and Welfare in Japan has granted marketing and manufacturing authorization for Dupixent® for the treatment of chronic obstructive pulmonary disease (COPD) in adults whose disease is not adequately controlled with existing therapy.

Scientists isolated perineural invasion-associated cancer-associated fibroblasts (CAFs), which demonstrated a markedly enhanced capacity to promote neural invasion in pancreatic cancer compared to non-perineural invasion-associated...

[Acta Pharmacologica Sinica] Researchers investigated whether and how PU.1/Spi1 regulated renal fibroblast activation during acute kidney injury.

[Nature Communications] Investigators developed synthetically tailored nucleus pulposus progenitor cells-derived exosomes with enhanced miR-221-3p expression and nucleus pulposus cells uptake capacity, which were integrated into an injectable hydrogel based on ECM analogues.

[BMC Cancer] CAFs contribute to tumor development by secreting exosomal miRNAs that promote proliferation, invasion, and resistance. The authors evaluate the impact of CAF-derived miRNAs on head and neck malignancies.